As shown by Green and Richter (1937), adrenochrome pigments are oxidative products of epinephrine (epinephrine). Both compounds are unstable, but Braconier et al. (1943) found that the resulting compound adrenal pigment monoaminoglycide (chromium carbazole) is stable when the adrenal pigment is bound to monoaminoglycide. This substance is poorly soluble but becomes more soluble in the form of sodium salicylate complexes, which can be administered intramuscular or orally. The compound's official name is chromium carbozolium salicylate.
Adrenochrome pigments (CAS: 54-06-8) belong to a class of organic compounds known as indoles and their derivatives. These are organic compounds containing indole, a two-ring system consisting of a six-membered benzene ring fused with a five-membered nitrogenous pyrrole ring. Adrenochrome pigment is a red oxidation product of epinephrine (epinephrine) first isolated and identified by Green and Richter in 1937 (PMID: 16746378). It is highly soluble in water. Adrenochrome can be oxidized by silver oxide to synthesize epinephrine pigment
Adrenochrome and tranexamic acid (1.6% each) were the least prescribed drugs in this group.
Oxidative stress leads to impaired contractile function, improper calcium management, cell death and ventricular remodeling. Adrenal pigment induces cardiomyocyte apoptosis [27]; Angiotensin II promotes the release of aldosterone, which acts on the kidneys to promote water and salt retention.
"The role of superoxide anion in the automatic oxidation of adrenochrome to epinephrine pigment and a simple determination of superoxide dismutase", Journal of Biochemistry, vol.
