Tacrolimus, also known as FK506, is the first-line drug for immunosuppressive therapy after organ transplantation. It has a chemical structure of a macrolide compound and is mainly used for anti-rejection in liver, kidney, heart, lung and bone marrow transplantation in China. reaction. In case of improper use, poisoning will occur, and common manifestations include cardiovascular system manifestations, nervous system manifestations, respiratory system manifestations, etc.
1. The mechanism of action of tacrolimus
Tacrolimus is a potent immunosuppressant. The mechanism of action is similar to that of cyclosporine, but the clinical effect is better than that of cyclosporine. Inhibits T cell activation and inhibits T cell-dependent B cell proliferation. It also inhibits the production of lymphokines such as interleukin-2, interleukin-3 and gamma-interferon and the expression of interleukin-2 receptors.
2. Precautions for the use of tacrolimus
(1) The adverse reactions of tacrolimus include: neurotoxicity, nephrotoxicity, drug-induced liver injury, hyperkalemia, diabetes, abnormal blood sugar, anemia, etc. medicine improved.
(2) During the treatment with tacrolimus, blood drug concentration and biological indicators should be monitored regularly. Once adverse reactions occur, the attending physician should be notified to deal with them in time, and the drug should not be stopped and reduced at will.
(3) During the use of tacrolimus, due to neurotoxicity, visual and nervous disorders may occur, so it is not recommended to drive or operate dangerous machinery. At the same time, this effect may be aggravated by drinking, and should be avoided after taking tacrolimus drinking.
(4) Tacrolimus cannot be used together with cyclosporine to avoid excessive suppression of the immune system.
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