Ciclosporin and Tacrolimus are immunosuppressive drugs. They help protect new organs after transplantation surgery. Methylprednisolone is sometimes used in conjunction with these drugs to prevent organ rejection, but they also interact with each other.
The interaction between Ciclosporin and methylprednisolone is bidirectional. Taking both drugs at the same time will increase the risk of side effects of both drugs, including possible Seizure. Methylprednisolone may also reduce the level of Ciclosporin in your body, reducing its effect.
The interaction between methylprednisolone and Tacrolimus is more unilateral. It can reduce the content of Tacrolimus in the body and reduce its effect. In addition, the severity of this interaction depends on the dosage of methylprednisolone. A higher dose of methylprednisolone will lead to a decrease in the content of Tacrolimus in the body. If Tacrolimus and methylprednisolone are taken at the same time, doctors may need to increase the dose of Tacrolimus.
You may have heard of Antiviral drug Paxlovid (nirmatrelvir/ritonavir) in the media. It can help reduce the risk of hospitalization and death due to COVID-19. However, it has many interactions that need to be noted. One possible interaction is with Corticosteroid such as methylprednisolone.
Paxlovid can increase the amount of methylprednisolone in the body. This increases the risk of side effects of methylprednisolone. To address this issue, your healthcare provider may reduce your dosage. Or they may recommend a different drug instead of methylprednisolone. Prednisone is another option that does not interact with Paxlovid.
In order for live vaccines to work best, your immune system needs to be in optimal condition. But Corticosteroid can reduce the strength of the immune system. This may reduce the effectiveness of live vaccines in preventing diseases.
Most importantly, live vaccines contain a weakened form of bacteria that it hopes to teach your body. If your immune system is not in its optimal state, the vaccine may mistakenly cause infection.
Therefore, when you take methylprednisolone, your healthcare provider may want to delay giving you a live vaccine. Examples of live vaccines include:
Treatment of pulmonary tuberculosis with BCG vaccine vaccine
Measles, mumps, and rubella (MMR)
Oral typhoid fever (in vivo typhoid fever)
Oral cholera
Rotarix
These risks are highest for high-dose methylprednisolone (what is methylprednisolone). Taking high-dose methylprednisolone for 14 days (2 weeks) or longer can weaken your immune system to some extent. In this case, it is best to wait for one month before receiving the live vaccine after discontinuing methylprednisolone.
Although there is no direct interaction between the two, you may need to be careful when drinking methylprednisolone.
Alcohol and methylprednisolone can both suppress the immune system. This makes infection (or recovery from infection) easier, especially when you drink heavily. Alcohol and methylprednisolone can also cause stomach bleeding. Using both can be a dangerous combination for your stomach.
It is best to avoid drinking alcohol when taking methylprednisolone. However, if you are interested in drinking moderately while taking Corticosteroid such as methylprednisolone, please consult your health care provider to understand the risks of doing so.
When should I contact my healthcare provider regarding the interaction of methylprednisolone?
The best way to manage interactions is to prevent them from happening from the beginning. Try putting all your Over-the-counter drug and prescription drugs on an up-to-date list. Before you start taking it, your pharmacist and healthcare provider can check the interaction of methylprednisolone.
In rare cases, even if you ask others to check your medication list, there will still be interactions. If you are worried about drug interactions at any time, be sure to contact your healthcare provider or pharmacist as soon as possible. Drug interaction increase the risk of side effects, which are sometimes dangerous. If you notice that any worrying side effects or side effects will not disappear, please contact your healthcare provider immediately.
Methylprednisolone is a Corticosteroid that reduces inflammation. It interacts with several drugs and vaccines, including blood thinners, Nonsteroidal anti-inflammatory drug and diabetes drugs. To prevent interactions, ensure that your pharmacist and healthcare provider have the latest list of medications you are taking.
