Synthesis of N-stearoyl glutamic acid

Synthesis of N-stearoyl glutamic acid (C18-Glu), a new gelator with multi-H-bonding sites, and n-stearoyl glutamic acid diethyl ester (C 18-Glu-2ES) were reported. The previously reported synthetic route of C18-Glu is that stearoyl chloride was dropwise added into disodium L-glutamate solution in a mixture of acetone and water (J. Am. Oil Chem. Soc. 1972, 49, 157 and Langmiur, 2001, 17, 1317). However, our experimental results indicated that one of the by-product HCl, could catalyze the yielded C 18-Glu to react further with L-glutamate to give more side-products. Therefore, the further workup became more difficult and the pure C 18-Glu was difficult to be obtained. Here, we synthesized C 18-Glu by the following two routes. One is from L-glutamic diethyl ester and stearic acid using dicyclohexylcarbodiimide (DCC) as a catalyzer. The other is from stearoyl chloride and n-stearoyl glutamic acid. These two synthetic routes can all give out C18-Glu with satisfactory characteristic data. Moreover, The gelating properties of C18-Glu and C18-Glu-2ES were also investigated. C18-Glu can gel chloroform and 1:1 mixed ethanol/water, while C18-Glu-2ES can form organogels in more solvents such as petroleum ether, hexane, acetone, ethanol, and 3:7 mixed ethanol/water. AFM images indicated that C18-Glu self-assembled into nanowires in chloroform, while C18-Glu-2ES into lamellar-like microstructures in 3:7 mixed ethanol/water.
The complete value chain and downstream and upstream essentials are scrutinized in this report. Essential trends like globalization, growth progress boost fragmentation regulation ecological concerns. This Market report covers technical data, manufacturing plants analysis, and raw material sources analysis of N-stearoyl Glutamic Acid Industry as well as explains which product has the highest penetration, their profit margins, and R D status. The report makes future projections based on the analysis of the subdivision of the market which includes the global market size by product category, end-user application, and various regions.
BLUE 1AL-ASG4 is a fine blue powder composed of Blue 1 Lake (And) N-stearoyl Glutamic Acid. It is surface treated with N-stearoyl Glutamic Acid (ASG) Treatment, an Amino Acid coating that offers hydrophobic properties. It gives good skin adhesion and a great creamy feel, especially in powders.
The invention discloses a stearoyl amino acid compound. The N-stearoyl Glutamic Acid compound possesses antioxidant activity, and is represented by formula (I); R1 is used for representing H or C1-6 linear alkyl or C1-6 branched alkyl, wherein the C1-6 linear alkyl or the C1-6 branched alkyl can be substituted by one or a plurality of substituent groups, and the substituent groups are selected from hydroxyl, amino, sulfydryl, carboxyl, aryl, acylamino, alkyl sulphanyl, or five-member heterocycle or seven-member heterocycle with 1 to 2 nitrogen atoms; R2 is used for representing H or C1-4 alkyl; and R3 is used for representing C11-25 saturated aliphatic hydrocarbon or unsaturated aliphatic hydrocarbon. The invention also discloses a preparation method and applications of the N-stearoyl Glutamic Acid compound. The N-stearoyl Glutamic Acid compound is capable of preventing N-stearoyl Glutamic Acid induced cell oxidative damage, possesses excellent antioxidant activity, can be used for preparing antioxidants, and possesses a promising application prospect.